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Dorjay, Tsewang
- Toxic Evaluation of Subchronic Exposure to Cadmium, Imidacloprid, and their Combination on Hematological Parameters in Buffalo Calves
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Authors
Affiliations
1 Department of Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana - 141012, Punjab, IN
1 Department of Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana - 141012, Punjab, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 22, No 3 (2015), Pagination: 46-51Abstract
The present investigation was undertaken to evaluate hematological alterations induced by oral subchronic exposure to cadmium, imidacloprid, and their combination in buffalo calves. Cadmium exposure produced a significant decrease in hemoglobin (Hb) concentration, Total Erythrocyte Count (TEC), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and MCH Concentration (MCHC). There was a significant increase in Total Leukocyte Count (TLC) but it did not produce any change in Erythrocyte Sedimentation Rate (ESR). Repeated oral administration of imidacloprid produced a significant decrease in Hb, PCV, TEC, MCV, MCH, and MCHC; however, there was a significant elevation in the levels of ESR and TLC. The combined exposure of cadmium and imidacloprid produced a significant decline in Hb concentration, PCV, TEC, MCV, and MCHC. It produced a significant increase in ESR and TLC, but no changes were observed in the levels of MCH.Keywords
Buffalo Calves, Cadmium, Imidacloprid, Subchronic, Toxicity.
References
- Goyer R. Toxic effect of metal. In: Klaassen CD, editor. Casarett and Doull’s Toxicology. The Basic Science of Poisons. 5th ed. New York: McGraw-Hill; 1995. p. 691–736.
- Jarup L, Berglund M, Elinder CG, Nordberg G, Vahter M. Health effects of cadmium exposure– A review of the literature and a risk estimate. Scand J Work Environ Health 1998; 24 Suppl 1:1–51.
- Jarup L, Hellström L, Alfven T, Carlsson MD, Grubb A, Persson B, et al. Low level exposure to cadmium and early kidney damage: THe OSCAR study. Occup Environ Med 2000; 57:668–72.
- Llobet JM, Granero S, Torres A, Schuhmacher M, Domingo JL. Biological monitoring of environmental pollution and human exposure to metals in Tarragona, Spain III. Blood levels. Trace Elem Electrolytes. 1998; 15:76–80.
- Lafuente A, Márquez N, Pérez-Lorenzo M, Pazo D, Esquifino AI. Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat. Food Chem Toxicol. 2000; 38:913–23.
- Quintas G, Armenta S, Garrigues S, Guardia MD. Fourier transform infrared determination of imidacloprid in pesticide formulations. J Braz Chem Soc. 2004; 15:307–12.
- Kidd H, James D. Agrochemicals Handbook. 3rd ed. Cambridge, England: Royal Society of Chemistry; 1994.
- Shimomura M, Okuda H, Matsuda K, Komai K, Akamatsu M, Sattelle DB. Effects of mutations of a glutamine residue in loop D of the alpha7 nicotinic acetylcholine receptor on agonist profiles for neonicotinoid insecticides and related ligands. Br J Pharmacol. 2002; 137:162–9.
- Benjamin MM. Outline of veterinary clinical pathology. 3rd ed. Ludhiana, India: Kalyani Publisher; 1985. p. 25, 48, 60.
- Kostic MM, Ognjanovic B, Dimitrijevic S, Zikic RV, Stajn A, Rosic GL, et al. Cadmium-induced changes of antioxidant and metabolic status in red blood cells of rats: In vivo effects. Eur J Haematol. 1993; 51:86–92.
- Hiratsuka H, Katsuta O, Toyota N, Tsuchitani M, Umemura T, Marumo F. Chronic cadmium exposure-induced renal anemia in ovariectomized rats. Toxicol Appl Pharmacol. 1996; 137:228–36.
- Chun YS, Choi E, Kim GT, Choi H, Kim CH, Lee MJ, et al. Cadmium blocks Hypoxia-Inducible Factor (HIF)-1-mediated response to hypoxia by stimulating the proteasome-dependent degradation of HIF-1alpha. Eur J Biochem. 2000; 267:4198–204.
- Moore MR, Goldberg A, Yeung-Laiwah AA. Lead effects on the heme biosynthetic pathway. Relationship to toxicity. Ann N Y Acad Sci. 1987; 514:191–203.
- Turk JR, Casteel SW. Clinical biochemistry in toxicology. In: Kaneko JJ, Harvey JW, Bruss ML, editors. Clinical Biochemistry of Domestic Animals. 5th ed. San Diego: Academic Press; 1997. p. 829–44.
- Dacie JV, Lewis SM. Practical Haematology. 5th ed. Edinburgh: Churchill Livingstone; 1997. p. 580–2.
- Livingstone C, Kaur B, Sandhu HS, Kaur R. Toxic effects of subacute oral exposure of imidacloprid on biochemical parameters in crossbred cow calves. Toxicol Int. 2006; 13:43–7.
- Hassan GA, Salem MH, Aba-Allah GA, Shahar N, Tohraa AE. Effect of organophosphorus (dimethoat) and pyrithroid pesticide on plasma level of cortisol and thyronine and on some haematological characteristics in growing male rabbits. Indian J Anim Sci. 1988; 58:1395–401.
- Gossett KA. Anemias associated with drugs and chemicals. Schalm’s Veterinary Haematology. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2004. p. 185–9.
- Toxic Effects of Sub-chronic Oral Exposure of Imidacloprid on Biochemical Parameters in Buffalo Calves
Abstract Views :88 |
PDF Views:0
Authors
Affiliations
1 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab,, IN
1 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab,, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 27, No 3&4 (2020), Pagination: 86-92Abstract
Imidacloprid, is a highly effective and widely used neonicotinoid insecticide for crop protection and veterinary pest control, which has gained a major market control in the past several years. The present investigation was undertaken to evaluate the toxic potential of imidacloprid in buffalo calves when administered for prolonged periods. Evaluation of various biochemical markers of hepatic, renal and muscular injury was done using standardized procedures. Oral administration of imidacloprid (@ 0.5 mg/kg/day; 90 days) in male buffalo calves, produced varying degrees of nasal discharge, lachrymal discharge, lethargy and weakness. Imidacloprid exposure caused a significant increase in the levels of plasma aspartate aminotransferase (12.3%), alanine aminotransferase (172.2%), lactate dehydrogenase (13.7%), gamma-glutamyltranspeptidase (57.5%), alkaline phosphatase (37.2%), acid phosphatase (220.0%), blood urea nitrogen (148.4%), creatinine (5.22%) and cholesterol (68.9%). However, no significant changes were observed in the enzymatic activity of creatine kinase, plasma cholinesterase as well as total protein and glucose levels.Keywords
Biochemical, Buffalo Calves, Imidacloprid, Subchronic.References
- Quintas G, Armenta S, Garrigues S, Guardia MDL. Fourier transform infrared determination of imidacloprid in pesticide formulations. Journal of the Brazilian Chemical Society. 2004; 15(2):307–12. https://doi.org/10.1590/S0103-50532004000200023
- Kidd H, James D. Agrochemicals Handbook. Third Ed. Cambridge, England: Royal Society of Chemistry; 1994.
- Tomizawa M, Cowan A, Casida JE. Analgesic and toxic effects of neonicotinoid insecticides in mice. Toxicology and Applied Pharmacology. 2001; 177:77–83. https:// doi.org/10.1006/taap.2001.9292
- Shimomura M, Okuda H, Matsuda K, Komai K, Akamatsu M, Sattelle DB. Effects of mutations of a glutamine residue in loop D of the alpha7 nicotinic acetylcholine receptor on agonist profiles for neonicotinoid insecticides and related ligands. British Journal of Pharmacology. 2002; 137:162–9. https://doi.org/10.1038/sj.bjp.0704848
- Tomizawa M, Casida JE. Imidacloprid, thiacloprid and their imine derivatives upregulate the alpha 4 beta 2 nicotinic acetylcholine receptor in M10 cells. Toxicology and Applied Pharmacology. 2000; 169:114–20. https://doi.org/10.1006/taap.2000.9057
- Wismer TN. Insecticides. Clinical Veterinary Toxicology; Plumlee, K. H., Ed.; St. Louis: Mosby; 2004. p. 184-85.
- Thyssen J, Machemer L. Imidacloprid: Toxicology and Metabolism. Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor; Yamamoto I, Casida J. E. Eds.; Springer-Verlag: Tokyo; 1999; 9:213–22. https://doi.org/10.1007/978-4-431-67933-2_9
- Reagan WJ, Yang RZ, Park S, Goldstein R, Brees D, Gong DW. Metabolic adaptive ALT isoenzyme response in livers of C57/BL6 mice treated with dexamethasone. Toxicol Pathol. 2012; 40(8):1117–27. https://doi.org/10.1177/0192623312447550
- Balani T, Agrawal S, Thaker AM. Hematological and biochemical changes due to short-term oral administration of imidacloprid. Toxicology International. 2011; 18(1):2–4. PMid: 21430911. https://doi.org/10.4103/0971-6580.75843
- Bhardwaj S, Srivastava MK, Kapoor U, Srivastava LP. 90 days oral toxicity of imidacloprid in female rats: Morphological, biochemical and histopathological evaluations. Food and Chemical Toxicology. 2010; 48(5):1185–90. PMid: 20146932. https://doi. org/10.1016/j.fct.2010.02.009
- Kaur B, Sandhu HS, Kaur R. Toxic effects of subacute oral exposure of imidacloprid on biochemical parameters in crossbred cow calves. Toxicology International. 2006; 13(1):43–7.
- Siddiqui MA. Toxicological and immunological studies of sub acute exposure of cockerels to imidacloprid and quinalphos. [M.V. Sc. Thesis]. Anand: Gujarat Agricultural University; 2004.
- Katarzyna A, Hryniewicz-Jankowska A, Renata T. Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer. Cancer Letters. 2015; 358(1): 1–7. https://doi.org/10.1016/j.canlet.2014.12.035
- James EE, Elizabeth CW. Association of γ‐glutamyl transferase (GGT) activity with treatment and clinical outcomes in chronic hepatitis C (HCV). Hepatology. 2013; 57(5):1725–33. PMid: 23258530. https://doi.org/10.1002/hep.26203
- Nicole JF, BeverlyAK. Alkaline phosphatase: Beyond the liver. Veterinary Clinical Pathology. 2007; 36(3):223–33. https://doi.org/10.1111/j.1939-165X.2007.tb00216.x
- Rosol TJ, Capen CC. Calcium regulating hormones and diseases of abnormal mineral (Calcium, Phosphorus and Magnesium) metabolism. Kaneko J J, Harvey J W and Bruss M L (ed). Clinical Biochemistry of Animals. 5th edn. San Diego: Academic Press; 1997. p. 619–702. https://doi.org/10.1016/B978-012396305-5/50024-5
- Friedman LS, Brautbar N, Barach P, Wolfe A, Richter ED. Creatine phosphate kinase elevations signaling muscle damage following exposures to anticholinesterases: 2 sentinel patients. Archives of Environmental Health. 2003; 58(3):167–71. PMid: 14535577. https://doi.org/10.3200/AEOH.58.3.167-171
- Finco DR. Kidney function. Kaneko J J (ed). Clinical Biochemistry of Domestic Animals. 5th edn. San Diego: Academic Press; 1989. p. 447–84.
- Brar RS, Sandhu HS, Singh A. Veterinary clinical diagnosis by laboratory methods. New Delhi: Kalyani Publishers, Ludhiana; 2000.